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Issues and Alternatives for Safety Assessment of Macrocylic Lactones in Pglycoprotein Deficient Dogs
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10/23/2018 to 10/24/2018
When: Tuesday, October 23, 2018
8:00 AM
Where: Hilton Hotel & Executive Meeting Center
1750 Rockville Pike
Rockville, Maryland  20852
United States

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Currently, all animal health macrocyclic lactones are assessed for avermectin sensitivity in MDR1-deficient collie dogs during the drug development process.  Noted academic experts, regulatory bodies and major animal health companies have expressed concerns about this model, including lack of robust validation, false positive results, inter- and intra-animal variation, and animal welfare concerns.  This workshop will bring together key experts from academia, regulatory agencies and animal health pharmaceutical companies to evaluate issues and agree on viable alternatives to macrocyclic lactone sensitivity assessment.  Further, the meeting will include brainstorming sessions to discuss validation aspects of an alternative model and consider how this work could be done in a collaborative manner.

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Registration Fees

  • Federal Government employment registration: $300
  • All others: Early Registration $400 until Aug 31, late registration $550 after Sept 1



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